Not only is John Malkovich set to be in Spider-Man 4, but he also confirmed that he is playing "The Vulture", the film's main villain.
This is what BadTaste had to report...
Host Simona Ventura asked Malkovich about his role of Vulture in the movie, he not only didn't deny his involvement, but confirmed that he's waiting for the final script to be sent to him, and that the movie has been delayed. He also hopes that shooting will begin as soon as possible.